The tasks of the SMARTEST Research Centre are organized in Research Groups. They are the following:
- BCI – BusyEye – Business and Computational Intelligence: coordinator Prof. Pietro Ducange, deputy coordinator Dr. Riccardo Pecori
- BASIC – Basic and Applied Sciences for Information and Communications: coordinator Prof. Gennaro Amendola
- EC – Easy – Everything Connected: coordinator Prof. Massimo Vecchio, deputy coordinator Dr. Marco Martalò
- AuDiS – Automation, Diagnosis and Sensing: coordinator Dr. Vincenzo Suraci
- ILIS – Innovative e-Learning and Information Systems: coordinator Prof. Riccardo Botteri